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Tuberculosis is a direct infectious disease caused by an acid-resistant aerobic bacterium. Indonesia is
now ranked fifth in the world with the highest burden of pulmonary TB in the world. The estimated TB
prevalence for all cases is 660,000 (WHO, 2010) and the estimated incidence is 430,000 new cases
each year. While the MDR-TB rate is estimated at 2% of all TB cases, TB cases with re-treatment are
estimated to be around 6,300 MDR-TB cases each year. One of promoting healthy behavior, the role
of nurses through nursing interventions provides health education towards MDR-TB prevention
behavior for the success of treatment in TB patients. The researcher formulated the research problem
"is there an effect of health education on tuberculosis drug resistance prevention (MDR-TB) behavior
with the DOTS strategy in pulmonary TB patients? The design of this study used Quasi-Experimental
Design with the Pretest-Posttest Control Group Design approach. The sampling technique was by
consecutive sampling. Bivariate statistical test uses independent t-test and dependent t-test. The
number of samples of 63 respondents who will be divided into 3 intervention groups, namely groups
with 1 intervention, groups with 2 interventions and groups with 3 interventions. The study was
conducted at the Kramatjati Health Center in East Jakarta. The results of the study showed that the
provision of health pen 3 times gave an increase in the value of knowledge and prevention with pvalue of 0.005.